Cystatin C as a marker of the rapid development of the atherosclerosis in patients with diabetes mellitus and chronic kidney disease

Introduction . The relationship between kidney dysfunction and cardiovascular system is multifaceted. Thus, the value of such a potential marker glomerular filtration rate (GFR) as cystatin C cannot be underestimated predictor development complications atherogenesis factor in diabetes mellitus (DM) chronic disease (CKD). Objective was to evaluate role an patients with DM CKD. Materials methods study involved 514 aged 25 80 years (the group interest (n=449), control (n=65)). All underwent clinical laboratory tests, sonography lower extremities vessels brachiocephalic arteries (BCA). Results thickness intima-media complex increased increase level right carotid artery (CA) (from 0.80 [0.70; 0.90] mm 0.97 [0.90; 1.02] mm) left CA 0.90 [0.80; 0.94] 0.92 1.10] mm). Logistic regression analysis demonstrated that > 0.93 mg/l raises risk thickening by 2.5 times (OR 2.505, p=0.042) 5 when C>1.38 4.718, p=0.001). At same time, association homocysteine unreliable (p=0.058). ≥0.82 sensitivity 72 % specificity 52 allowed predict subclinical atherosclerosis CKD (ROC AUC – 0.739). Conclusion Cystatin not only highly sensitive accurate indicator GFR, capable detecting early stages renal dysfunction, but also effective predictive atherosclerotic process